ANR fMEG OPM

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MEG in fetuses (fMEG) and high-resolution electroencephalography (HR-EEG) have been developed at the fetal magnetoencephalography center in Tübingen and at Inserm 1105, Amiens, respectively, providing access to the abilities of the immature brain network from the last trimester of gestation in and ex utero. We will analyze with similar protocols the early development of the neuronal networks. Both spontaneous activity and event related cerebral responses to stimuli will be analysed by both approaches in and ex utero in Amiens and Tübingen. We will develop (1) Common paradigms for event related responses in MEG and HR-EEG. (2) Concurrent fMEG and HR-EEG, recordings in healthy prematures and fetuses of the same gestational age. (3) A dynamic estimator model from HR-EEG in premature to fMEG. (4) Adapt the tasks to the recordings performed in Amiens in fetuses and preterms with the new approach developed around the optically pumped magnetometer (OPM) by the Laboratoire d’Electronique et de Technologie de l’Information (CEA LETI), Grenoble. The complementary skills, HR-EEG in preterms in Amiens, fMEG in Tübingen and development of OPM in Grenoble, is a guarantee of success for this project.